Forced degradation studies were performed for prasugrel and aspirin on four different stress conditions in pharmaceutical dosage form by using validated spectrophotometric method. Degradation studies reveal the method capability on different stress condition. Absorption maxima was found to be 254.4 nm, 225.6 nm was for prasugrel and aspirin respectively without mutual interference. Isobestic point for both drugs was chosen at 238.4 nm. This method obeyed Beer’s law in the concentration range of 10-70 μg/ml for prasugrel and 2-26 μg /ml for aspirin. The results of the analysis have been validated statistically. Method proven to be rapid, precise and cost effective for the routine analysis in pharmaceutical dosage form.
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